Posts Tagged ‘safe plastics’

Bisphenol A Linked to Metabolic Syndrome in Humans

The University of Cincinnati has used human tissue for their study on “average” BPA exposure. Their findings, though not surprising, supports other independent research that BPA does affect human health.

Excerpt:
In a laboratory study, using fresh human fat tissues, the UC team found that BPA suppresses a key hormone, adiponectin, which is responsible for regulating insulin sensitivity in the body and puts people at a substantially higher risk for metabolic syndrome.
 
Metabolic syndrome is a combination of risk factors that include lower responsiveness to insulin and higher blood levels of sugar and lipids. According to the American Heart Association, about 25 percent of Americans have metabolic syndrome.  Left untreated, the disorder can lead to life-threatening health problems such as coronary artery disease, stroke and type 2 diabetes.
 
Nira Ben-Jonathan, PhD, and her team are the first to report scientific evidence on the health effects of BPA at environmentally relevant doses equal to “average” human exposure. Previous studies have primarily focused on animal studies and high doses of BPA.

How was the study conducted?

…the UC team collected fresh fat tissue from Cincinnati patients undergoing several types of breast or abdominal surgery. These samples included three types of fat tissue: breast, subcutaneous and visceral (around the organs).
 
Tissue was immediately taken to the laboratory and incubated with different concentrations of BPA or estrogen for six hours to observe how the varied amounts of BPA affected adiponectin levels. The effects of BPA were then compared to those of estradiol, a natural form of human estrogen.

What were the results?

They found that exposing human tissues to BPA levels within the range of common human exposure resulted in suppression of a hormone that protects people from metabolic syndrome.
 
“These results are especially powerful because we didn’t use a single patient, a single tissue source or a single occurrence,” she adds. “We used different fat tissues from multiple patients and got the same negative response to BPA.”

Again, very interesting findings. This does support other independent research, yet the FDA still claims the safety of BPA. I am really not all that surprised, yet I am in shock. I cannot believe with all this mounting evidence, they can stand by that claim.

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BPA impairs brain function in monkeys

Well, well, well… yet another independent study comes out that shows BPA is harmful at low-levels. This particular study, conducted at Yale, used monkeys, not rodents. Because primates are human’s closest relative, you can draw the conclusion that results in humans would be quite similar.

Excerpt:

“They also used lower levels of the chemical than in past studies. ‘Our goal was to more closely mimic the slow and continuous conditions under which humans would normally be exposed to BPA,’ said study author Csaba Leranth, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences and in Neurobiology at Yale. ‘As a result, this study is more indicative than past research of how BPA may actually affect humans.’”

How was the study conducted:

Over a 28-day period, Leranth and his team gave each primate 50 micrograms/kg of BPA per day, adjusted for body weight, the amount considered safe for human consumption by the Environmental Protection Agency (EPA). The team also administered estradiol, the major form of hormonal estrogen that modulates nerve cell connections in the brain. Best known as one of the principal hormone products of the ovary, estrogen has also been shown in past studies to be synthesized in the brain, where it aids the development and function of the hippocampus and prefrontal cortex.

And the results?

The team then used an electron microscope to count nerve cell connections in the brain. They found that BPA inhibits creation of the synaptic connections in the hippocampus and prefrontal cortex, areas of the brain involved with regulation of mood and formation of memory.

 “Our primate model indicates that BPA could negatively affect brain function in humans,” said study co-author Tibor Hajszan, M.D., associate research scientist in Yale Ob/Gyn. “Based on these new findings, we think the EPA may wish to consider lowering its ‘safe daily limit’ for human BPA consumption.”

Hajszan said that although daily exposure of an average person to BPA usually does not reach the level that was applied in this study, human exposure to BPA is not limited to a single month, but rather is continuous over a lifetime. “The negative effect of BPA may also be amplified when estradiol levels are naturally lower than in healthy adults. That is why exposure to BPA may particularly be risky in the case of babies and the elderly.”

Now, I don’t know about you, but the more studies such as this that are released, I am losing more and more confidence in the FDA, who are STILL claiming BPA is safe for human consumption. Obviously, they are still siding with the plastics industry and relying on biased research to draw their conclusion. Thanks to manufacturers taking things into their own hands, at least us parents who want BPA-free alternatives can get them readily. Hopefully thought the FDA will wake up, ban BPA, making our purchasing decisions much easier.
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Feds concerned about bisphenol-a (BPA)

It seems this “debate” will never end. Today the National Toxicology Program released a report sharing their findings of the safety of BPA.

“They concluded that current human exposure to the chemical, which is used in many polycarbonate plastics and epoxy resins, is of “some concern” for effects on development of the prostate gland and brain and for behavioral effects in fetuses, infants and children.”

This is no surprise to those of us who have been looking at the independent research, rather than relying on biased-industry research.

“As to how consumers should use this information, Michael Shelby, director of the program’s Center for the Evaluation of Risks to Human Reproduction said in a press release, ‘Unfortunately, it is very difficult to offer advice on how the public should respond to this information. More research is clearly needed to understand exactly how these findings relate to human health and development, but at this point we can’t dismiss the possibility that the effects we’re seeing in animals may occur in humans.  If parents are concerned, they can make the personal choice to reduce exposures of their infants and children to BPA.’”

The report also expressed minimal concern for BPA accelerating puberty in females and negligible concern that pregnant women exposed to BPA can result in fetal or neonatal mortality, birth defects or reduced birth weight and growth in their offspring. There is also negligible concern that BPA causes reproductive effects in non-occupationally exposed adults and minimal concern for those adults exposed to higher levels at their job.

And what does the dear FDA think about this?

“’We are pleased to see the finalization of the NTP report,’ said Frank Torti, the Principal Deputy Commissioner and chief scientist at the FDA. ‘The FDA will consider this final report in our role as a regulatory agency and joins NTP in the call for additional research in this important area.’”

In other words – just a bunch of hogwash. The FDA continues, time and time again, to protect the industries, not the American public. I have pretty much decided that if the FDA has approved something and declares it “safe,” then avoid it. I try to look at the EU and other agencies who actually care about the health and well-being of its citizens. Any faith I have had in the FDA is lost.

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